A Potential Bioactive Secondary Metabolites and Antimicrobial Efficacy of Streptomyces thermocarboxydus Strain KSA-2, Isolated from Kali River, Karwar
Volume 1, Issue 1, Article 2 - 2020
Authors: Sreenivasa Nayaka;Muthuraj R.;Bidhayak Chakraborty ;Meghashyama Prabhakara Bhat ;Pallavi S.S. ;Shashiraj K.N.;Halaswamy H.M.;Dhanyakumara S.B.;Dattatraya Airodagi;Kavitha Haged
Copyright © 2020 . This is an open access article distributed under the Creative
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In the present study, an Actinomycetes strain KSA-2 was isolated from freshwater sediment samples of Kali River, Karwar, Karnataka, India. The strain KSA-2 was selected among seven isolates based on primary screening of antimicrobial activity against pathogenic organisms. The morphological physiological and biochemical characterizations were performed, the bioactive secondary metabolites were produced in liquid broth culture and was characterized by UV-Vis. spectroscopy and FTIR spectroscopy. Later, the potent KSA-2 strain was identified by 16S rRNA gene sequencing (1366 bp) and a phylogenetic tree was constructed and the strain KSA-2 was confirmed as Streptomyces thermocarboxydus strain KSA-2. Further, the characterization of methanolic extract by UV-Vis. and FTIR spectroscopy analysis revealed the presence of broad spectrum of antimicrobial and other compounds and alkyl halides, alkenes, sulfoxide, carboxylic acids, alkanes respectively.