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Comparative study of the action of fluoroquinolones and vancomycin on biofilms of Staphylococcus strains isolated from infections of peritoneal dialysis catheters
| Received Date | Revised Date | Accepted Date | Publication Date |
| 5/1/2021 | 30/1/2021 | 13/3/2021 | 2/8/2021 |
Abstract
Background: catheter mediated infections are mainly caused by Staphylococci, the treatment of these infections is challenging because of biofilm formation. Methods: A microtiter plate biofilm assay was used to study the in vitro activity of Vancomycin, Ofloxacin and Levofloxacin on preformed biofilms of 30 stains of Staphylococcus isolated from peritoneal dialysis catheters and fluids at concentrations like those used intraperitoneally. Results: The in vitro action of the three antibiotics on preformed biofilms was statistically significant. it was significantly higher for Ofloxacin and Levofloxacin rather than that of Vancomycin. Discussion: the results demonstrate the effectiveness of the three antibiotics at concentrations like those used intraperitoneally and the superiority of Fluoroquinolones activity on Staphylococcal biofilms, these results correlate with the conclusions of other authors.
Keywords: Biofilm, fluoroquinolones, vancomycin, peritoneal dialysis, catheters
How To Cite This Article
Rabhi , A.Mahrane , S.Nouar , S.Boushaki , R.Benkherif , A.Guechi , Z. & Belkacem , H. A. (2021). Comparative study of the action of fluoroquinolones and vancomycin on biofilms of Staphylococcus strains isolated from infections of peritoneal dialysis catheters . Current Research in Microbiology and Infection, 2 (1), 1-4, 10.31559/CRMI2021.2.1.1
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