Clinicopathological studies on the remodeling effect of Platelet-Rich plasma on lung fibrosis induced by amiodarone in Albino rats

Volume 1, Issue 3, Article 8 - 2020

Authors: Zainab M. Maher;Abdel-rahman A. Elsayied ;Mouchira M. Mohi El-Din

Copyright © 2020 . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract

Objectives: This study aimed to evaluate the role of platelet rich plasma (PRP) in the treatment of lung fibrosis induced by amiodarone drug. Materials and Methods: Seventy adult male Wistar albino rats were divided into three groups (n=20) plus ten rats were used for PRP collection. The first group used as control group. The rats in second group (gp.2) were injected intraperitoneally (i.p.) daily with amiodarone drug at (80 mg/ kg. bwt) for three weeks, then injected (24 hours after last dose of amiodarone) (i.p.) with phosphate buffer saline (PBS) (0.5 ml/ kg. bwt) two times weekly for three weeks. The rats in third group (gp.3) were injected (i.p.) daily with amiodarone drug at (80 mg/ kg. bwt) for three weeks, plus (i.p.) injection with platelet rich plasma (PRP) at dose (0.5 ml/kg. bwt) (24 hours after last dose of amiodarone injection) two times weekly for three weeks. The animals were examined during the experiment and sacrificed at the end of the experiment. Results: Rats in the PRP treatment (gp. 3) showed an increase in the level of WBCs and RBCs counts in comparison with group 2. Significant increase in glutathione reductase and a significant decrease in malondialdehyde levels were detected in group 3 when compared with group 2. The histopathological findings showed an improvement in the fibrosed lungs compared to gp (2). Conclusions: This study concluded the remodeling effect of PRP, which was observed clinically and pathologically against the harmful effects of amiodarone in albino rats.

How To Cite This Article

Maher et al. Clinicopathological Studies on the Remodeling Effect of Platelet-Rich Plasma on Lung Fibrosis Induced by Amiodarone in Albino Rats. Veterinary Medicine and Public Health Journal 1(3); 2020: 108-114
https://doi.org/10.31559/vmph2020.1.3.8