The study aimed to establish the occurrence of cutaneous mesenchymal and melanocytic neoplasm’s from various breeds of cattle belonging to different geographical locations of Puducherry and Tamil Nadu, India. Out of 100 cases with cutaneous growths studied, 89 cases were diagnosed as neoplastic and 11 as non-neoplastic conditions based on gross, histological and histochemical features. Out of 89 cutaneous neoplasms, 5 (5.61%) cases were of mesenchymal and 4 (4.49%) were of melanocytic in origin. Grossly, the lesions varied in size, greyish-white to dark in colour, solitary to multiple, sessile to pedunculated, cauliflower to rice grain-like, soft to hard in consistency and occasionally were ulcerated. Histopathologically, proliferating spindle-shaped fibroblasts with oval normochromatic nuclei and abundant collagen arranged in whorls were the features in all the mesenchymal neoplasms and were diagnosed as fibroma. The melanocytic tumours revealed proliferating melanocytes were plump to fusiform with granular hyper-pigmented cytoplasm comprising of melanin and often arranged as nests were accordingly classified as melanoma.